Ahmed Roshdi Hamed Ahmed graduated at Faculty of Medicine, Sohag University, Egypt on 2000. He started his training at Pathology Department, Sohag University Hospitals to get Master of Pathology on 2003. He fi nished his PhD studies at the Northern Institute for Cancer Research, Newcastle University, UK on 2011 before starting his current career as a Lecturer Pathology, Sohag University. He is a member of Medical Ethics Committee, Sohag Faculty of Medicine since 2013 and an Assistant Consultant of Surgical Pathology at Sohag Cancer Institute since 2012. He published 10 articles in national and international journals and had several conference participations.
Rhinoscleroma (RS) is a progressive chronic specifi c disease of the nose and upper respiratory passages caused by Klebsiella rhinoscleromatis bacilli. It is endemic in Egypt and in sporadic areas worldwide. Diagnosis of RS is based on identifi cation of the pathognomonic Mickulicz cells (MCs) which is most prominent during granulomatous phase but spares or absent during initial catarrhal or late sclerotic phases of the disease. Th is study aimed to identify the potential diagnostic features of nasal RS when MCs are absent. A total of 125 nasal biopsies from patients complaining of chronic nasal symptoms were retrieved for this study; including 72 chronic nonspecifi c infl ammatory lesions and 53 RS diagnosed by PAS and Geimsa stains. Th e detailed histological diff erences among the two groups were measured statistically. RS was frequently a bilateral disease (p<0.05) of young age (p<0.001) with a female predominance (p<0.05) and usually associated with nasal crustations (p<0.001). Five strong histological indicators of RS were specifi ed by univariate binary logistic regression analyses including squamous metaplasia (OR 27.2, p<0.0001), dominance of plasma cells (OR 12.75, p<0.0001), Russell bodies (OR 8.83, p<0.0001), neutrophiles (OR 3.7, p<0.001) and absence of oesinophiles (OR 12.0, p<0.0001). According to Multivariate analysis dominance of plasma cells and absence of oesinophiles were the strongest diagnostic features of RS. Th e diagnostic model using these two features confi rmed or excluded RS in 84.3% of the investigated cases. Based on this study, the diagnostic features of RS in absence of MCs can be classifi ed into major criteria including dominance of plasma cells infi ltration and absence of oesinophiles and minor criteria including young age, female gender, bilateral nasal involvement, nasal crustation, squamous metaplasia, Russell bodies, and neutrophiles.
Background: Infl uenza viruses are an important cause of disease of varying severity in humans. Complications of infl uenza may occur at any age, aff ecting mostly infants and children. Th e aim of the study was to describe the course of infl uenza among children aged 0-59 months. Material & Methods: Th e total number of 150 children with infl uenza-like symptoms (ILI): Cough, fever >37.8°C, sore throat was included into the observation. All children were tested with both rapid infl uenza detection test (RIDT) BD Directigen™ EZ Flu A+B® and RT-PCR. Th e total number of 64 cases of infl uenza was diagnosed (attack rate 40%): 19 (30%) cases of infl uenza caused by virus type B and 45 (70%) cases of infl uenza caused by type A virus. Results: Children with infl uenza required more oft en follow up visits (p<0.05, OR 1.99, 95% CI 1.03-3.85) and less oft en were administrated antibiotic therapy (p<0.05, OR 0.25, 95% CI 0.044-0.97). Th e logistic regression analysis revealed that only positive result of rapid infl uenza detection test, not any of clinical symptoms, could be found as the independent predictor of infl uenza (OR 4.37, 95% CI 2.03-9.43). Patients with infl uenza type A more oft en reported muscle ache (p<0.05) and complications (p<0.05; OR 6.06, 95% CI 1.2-60.38). Otits media occurred more oft en among patients with than without infl uenza (p<0.01), OR 15.5 95% CI 2.1-688.5). Conclusions: Obtained results indicate that although infl uenza infections among children younger than 59 months were generally mild and self-limited, paediatric burden of the disease was signifi cant.